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GSK 2334470, Tocris Bioscience™

Catalog No. p-4816516 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Highly potent, selective PDPK1 (PDK1) inhibitor

Potent 3-phosphoinositide-dependent protein kinase (PDPK1) inhibitor (IC50 ∽ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK in vitro; exhibits limited inhibitory effect on Akt activation. Delays melanomagenesis and metastasis in BrafV600E::Pten(-/-) mice.

Chemical Identifiers

CAS 1227911-45-6
Molecular Formula C25H34N8O
Molecular Weight (g/mol) 462.602
InChI Key QLPHOXTXAKOFMU-WBVHZDCISA-N
Synonym 3s,6r-1-6-3-amino-1h-indazol-6-yl-2-methylamino-4-pyrimidinyl-n-cyclohexyl-6-methyl-3-piperidinecarboxamide, 3s,6r-1-6-3-amino-1h-indazol-6-yl-2-methylamino pyrimidin-4-yl-n-cyclohexyl-6-methylpiperidine-3-carboxamide, d0eu1r, pdk1 inhibitors, glaxosmithkline, gsk hplc, 3-piperidinecarboxamide, 1-6-3-amino-1h-indazol-6-yl-2-methylamino-4-pyrimidinyl-n-cyclohexyl-6-methyl-, 3s,6r
PubChem CID 46215815
IUPAC Name (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide
SMILES CC1CCC(CN1C2=NC(=NC(=C2)C3=CC4=C(C=C3)C(=NN4)N)NC)C(=O)NC5CCCCC5

Specifications

Quantity 10 mg
Formula Weight 462.59
Percent Purity >98%
Chemical Name or Material GSK 2334470

Safety and Handling

Recommended Storage Store at +4°C
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