GW 5074, Tocris Bioscience™

Description

Potent, selective c-Raf1 kinase inhibitor

GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). GW 5074 displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW 5074 binds mutant huntingtin (mHTT) and decreases levels of mHTT in cultured hippocampal neurons and fibroblasts from patients with Huntington's disease. Brain penetrant.

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Specifications

Chemical Identifiers

• CAS: 220904-83-6
• Molecular Formula: C15H8Br2INO2
• Molecular Weight (g/mol): 520.95
• MDL Number: MFCD09971042
• InChI Key: LMXYVLFTZRPNRV-UHFFFAOYSA-N
• Synonym: raf1 kinase inhibitor i, chembl72365, insolution raf1 kinase inhibitor i, 5-iodo-3-3,5-dibromo-4-hydroxyphenyl methylene-2-indolinone, 3-3,5-dibromo-4-hydroxy-benzylidene-5-iodo-1,3-dihydro-indol-2-one, 3z-3-3,5-dibromo-4-hydroxyphenyl methylidene-5-iodo-1h-indol-2-one, z-3-3,5-dibromo-4-hydroxybenzylidene-5-iodoindolin-2-one, gw5074, powder, tocris-1381, biomolki_000056
• PubChem CID: 5924208
• IUPAC Name: 3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-2,3-dihydro-1H-indol-2-one
• SMILES: OC1=C(Br)C=C(C=C2C(=O)NC3=C2C=C(I)C=C3)C=C1Br

• Quantity: 10 mg
• Formula Weight: 520.94
• Percent Purity: >98%
• Chemical Name or Material: GW 5074

Safety and Handling

Recommended Storage

Desiccate at -20°C