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  8. GW 583340 dihydrochloride, Tocris Bioscience™

GW 583340 dihydrochloride, Tocris Bioscience™

Catalog No. p-4784008 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent dual EGFR/ErbB2 inhibitor; orally active

Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ∽ 80% in a murine xenograft model following oral administration.

Chemical Identifiers

CAS 1173023-85-2
Molecular Formula C28H27Cl3FN5O3S2
Molecular Weight (g/mol) 671.024
InChI Key WIMITXDBYLKRKB-UHFFFAOYSA-N
Synonym gw583340 dihydrochloride, gw 583340 dihydrochloride, n-3-chloro-4-3-fluorophenyl methoxy phenyl-6-2-2-methanesulfonylethyl amino methyl-1,3-thiazol-4-yl quinazolin-4-amine dihydrochloride, d0hp5b, gw583340 dihydrochloride hplc , solid, 4-3-chloro-4-3-fluorophenyl methoxy phenylamino-6-2-2-methylsulfonyl ethyl aminomethyl-4-thiazolyl quinazoline dihydrochloride, n-3-chloro-4-3-fluorobenzyloxy phenyl-6-2-2-methylsulfonyl ethylamino methyl thiazol-4-yl quinazolin-4-amine dihydrochloride, n-3-chloro-4-3-fluorophenyl methoxy phenyl-6-2-2-methylsulfonyl ethyl amino methyl-4-thiazolyl-4-quinazolinamine dihydrochloride
PubChem CID 16219404
IUPAC Name N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]quinazolin-4-amine;dihydrochloride
SMILES CS(=O)(=O)CCNCC1=NC(=CS1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.Cl.Cl

Specifications

Quantity 10 mg
Formula Weight 671.03
Percent Purity >97%
Chemical Name or Material GW 583340 dihydrochloride

Safety and Handling

Recommended Storage Desiccate at +4°C
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