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GW 788388, Tocris Bioscience™

Catalog No. 326450 Shop All R&D Systems Products
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Potent and selective inhibitor of TGF-βRI

Potent inhibitor of transforming growth factor-β type I receptor (ALK5) (IC50 values are 18 and 93 nM for ALK5 binding and for TGF-β cellular assay respectively). Inhibits esophageal squamous cell carcinoma (ESCC)-induced neoangiogenesis. Orally active.

Chemical Identifiers

CAS

452342-67-5

Molecular Formula

C25H23N5O2

Molecular Weight (g/mol)

425.49

MDL Number

MFCD16038936

InChI Key

SAGZIBJAQGBRQA-UHFFFAOYSA-N

Synonym

4-4-3-pyridin-2-yl-1h-pyrazol-4-yl pyridin-2-yl-n-tetrahydro-2h-pyran-4-yl benzamide, n-oxan-4-yl-4-4-3-pyridin-2-yl-1h-pyrazol-4-yl pyridin-2-yl benzamide, 4-4-3-pyridin-2-yl-1h-pyrazol-4-yl pyridin-2-yl-n-tetrahydropyran-4-yl benzamide, d0c3ad, benzamide, 4-4-3-2-pyridinyl-1h-pyrazol-4-yl-2-pyridinyl-n-tetrahydro-2h-pyran-4-yl, 4-4-3-pyridin-2-yl-1h-pyrazol-4-yl pyridin-2-y, n-oxan-4-yl-4-4-5-pyridin-2-yl-1h-pyrazol-4-yl pyridin-2-yl benzamide, n-oxan-4-yl-4-4-3-pyridin-2-yl-2h-pyrazol-4-yl pyridin-2-yl benzamide, 4-4-5-pyridin-2-yl-1h-pyrazol-4-yl pyridin-2-yl-n-tetrahydro-2h-pyran-4-yl benzamide

PubChem CID

10202642

IUPAC Name

N-(oxan-4-yl)-4-{4-[5-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}benzamide

SMILES

O=C(NC1CCOCC1)C1=CC=C(C=C1)C1=NC=CC(=C1)C1=C(NN=C1)C1=CC=CC=N1

Specifications

Quantity

50 mg

Formula Weight

425.48

Percent Purity

>98%

Chemical Name or Material

GW 788388

Recommended Storage

Store at +4°C
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