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HBX 41108, Tocris Bioscience™

Catalog No. 428510 Shop All R&D Systems Products
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective USP7 inhibitor

Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

Chemical Identifiers

CAS 924296-39-9
Molecular Formula C13H3ClN4O
Molecular Weight (g/mol) 266.64
MDL Number MFCD16251537
InChI Key BIGPXXAUSQLTQR-UHFFFAOYSA-N
Synonym 7-chloro-9-oxo-9h-indeno 1,2-b pyrazine-2,3-dicarbonitrile, 7-chloro-9-oxo-9h-indeno 1,2-b-pyrazine-2,3-dicarbonitrile, 9h-indeno 1,2-b pyrazine-2,3-dicarbonitrile, 7-chloro-9-oxo, 7-chloro-9-oxoindeno 1,2-b pyrazine-2,3-dicarbonitrile, d0i9up, usp-7 inhibitors, hybrigenics, usp inhibitors cancer , hybrigenics, usp-7 inhibitors cancer , hybrigenics, usp-9 inhibitors cancer , hybrigenics, 7-chloro-9-oxo-indeno 1,2-b pyrazine-2,3-dicarbonitrile
PubChem CID 16065773
IUPAC Name 7-chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
SMILES ClC1=CC2=C(C=C1)C1=NC(C#N)=C(N=C1C2=O)C#N

Specifications

Quantity 10 mg
Formula Weight 266.64
Percent Purity >98%
Chemical Name or Material HBX 41108

Safety and Handling

Recommended Storage Store at -20°C
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