Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organonitrogen Compounds
  6. Secondary amines
  7. HLI 373, Tocris Bioscience™

HLI 373, Tocris Bioscience™

Catalog No. p-4817030 Shop All R&D Systems Products
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Hdm2 inhibitor; activates p53-dependent transcription

Inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.

Chemical Identifiers

CAS 1782531-99-0
Synonym 5-3-dimethylamino propyl amino-3,10-dimethylpyrimido 4,5-b quinoline-2,4 3h,10h-dione, ncistruc1_001893, ncistruc2_000706, 5-3-dimethylamino propylamino-3,10-dimethylpyrimido 4,5-b quinoline-2,4-dione
PubChem CID 435678

Specifications

Molecular Formula C18H25Cl2N5O2
Quantity 10 mg
InChI Key MADKBDHYUMEAOS-UHFFFAOYSA-N
SMILES Cl.Cl.CN(C)CCCN=C1C2=CC=CC=C2N(C)C2=C1C(=O)N(C)C(=O)N2
IUPAC Name 5-{[3-(dimethylamino)propyl]imino}-3,10-dimethyl-1H,2H,3H,4H,5H,10H-pyrimido[4,5-b]quinoline-2,4-dione dihydrochloride
Molecular Weight (g/mol) 414.33
Formula Weight 414.33
Percent Purity >99%
Chemical Name or Material HLI 373

Safety and Handling

Recommended Storage Desiccate at Room Temperature
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.