Invitrogen™ Human Calcium Channel beta-4 (aa 389-495) Control Fragment Recombinant Protein

Recombinant Protein

This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy. Multiple transcript variants encoding different isoforms have been found for this gene.

Accession Number

O00305

Concentration

≥5.0 mg/mL

For Use With (Application)

Blocking Assay, Control

Formulation

1M urea, PBS with no preservative; pH 7.4

Gene ID (Entrez)

785

Name

Calcium Channel beta-4

Quantity

100 μL

Storage Requirements

-20° C, Avoid Freeze/Thaw Cycles

Regulatory Status

RUO

Gene Alias

3110038O15Rik; CAB4; Cacnb4; CACNLB4; calcium channel beta 4 subunit; calcium channel voltage-dependent subunit beta 4; calcium channel, voltage-dependent, beta 4 subunit; calcium voltage-gated channel auxiliary subunit beta 4; Cchb4; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; EA5; EIG9; EJM; EJM4; EJM6; lh; OTTHUMP00000207247; OTTHUMP00000207249; Voltage-dependent L-type calcium channel subunit beta-4

Gene Symbol

Cacnb4

Conjugate

Unconjugated

Species

Human

Recombinant

Recombinant

Sequence

EHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDS

Expression System

E. coli

Form

Liquid