Invitrogen™ Human N-Ras Synthetic Peptide

Synthetic Peptide

N-RAS Synthetic Peptide, PEP-1603, from Invitrogen.

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. PEP-1603 can be used as a blocking peptide with polyclonal antibody PA5-34560. For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.

Gene ID (Entrez)

4893

Species

Human

Purification Method

purified

Accession Number

P01111

Common Name

Human N-Ras

Concentration

200 μg/mL

Content And Storage

-20°C

Description

Synthetic Peptide

Format

Liquid

Formulation

PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2

For Use With (Application)

Blocking Assay, Control

Gene Alias

N-RAS, Neuroblastoma RAS, NRAS, NRAS1, NS6, ALPS4, Neuroblastoma RAS viral (v-ras) oncogene homolog, RAS, RASN, GTPase Nras, Transforming protein N-Ras

Gene Symbol

NRAS

Lyophilized

No

Preservative

0.02% sodium azide

Product Type

Peptide

Quantity

50 μg

Regulatory Status

RUO - research use only

Storage Buffer

PBS