Gibco™ Human Plateable Hepatocytes, Uptake Qualified

Human Plateable Hepatocytes, Uptake Qualified

Cryopreserved human hepatocytes for use in transporter-mediated uptake applications.

Cells per vial: 4-8 million

Prototypical hepatic uptake transporter substrates taurocholate and estradiol-17β-glucuronide have been assessed to qualify the transport function of hepatic NTCP (SLC10A1) and OATP1B14/3 (SLCO1B1/3), respectively. The transport of each substrate (radiolabeled) was monitored by scintillation analysis and active transport values (37°C - 4°C) determined by linear regression.

Get the Results You Need with GIBCO™ Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro/in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.

Each lot is tested for:

Phase I and II enzyme activities

Proper morphology

Viabilities generally >75%

Attachment efficiency

Monolayer formation and integrity

For research use only. Not intended for human or animal therapeutic or diagnostic use.

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Cell Passage Number

Passage 0

Content And Storage

Vials of cryopreserved hepatocytes should be stored in a cryostorage dewar or -135°C freezer.

Cell Type

Hepatocytes

Culture Type

Adherent Cell Culture

Form

Cryopreserved

Species

Human

Donor Source

Single Donor

Format

Tube

No. of Cells

4-8 x 10⁶

Product Line

Gibco™

Product Type

Hepatocytes

Quantity

1.5 mL

For Research Use Only. Not for use in diagnostic procedures.