Thermo Scientific Chemicals Hydrocortisone, 98%

Hydrocortisone, CAS # 50-23-7, is the pharmaceutical formulation of the hormone, cortisol, and is commonly administered as an immunosuppressive drug.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• Hydrocortisone is the synthetic formulation of the naturally occurring hormone, cortisol
• It is available as a white crystalline powder soluble in water, DMSO, and ethanol
• It is stable at room temperature but sensitive to light, and reactive in the presence of strong oxidizing agents

Applications

• Hydrocortisone works as an agonist to glucocorticoid receptors, thereby suppressing the inflammatory response of the immune system
• It’s administration induces gluconeogenesis, thus increasing endogenous blood sugar levels
• Research indicates a role for hydrocortisone in the metabolism of fat, protein, and carbohydrates

Chemical Identifiers

CAS

50-23-7

Molecular Formula

C₂₁H₃₀O₅

Molecular Weight (g/mol)

362.47

MDL Number

MFCD00011654

InChI Key

JYGXADMDTFJGBT-VWUMJDOOSA-N

Synonym

hydrocortisone, cortisol, acticort, cetacort, cortef, 17-hydroxycorticosterone, hydrocortisyl, hydrasson, cobadex, cortril

PubChem CID

5754

ChEBI

CHEBI:17650

IUPAC Name

(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

SMILES

CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O

Melting Point

212°C to 217°C

Color

White

Infrared Spectrum

Authentic

Assay Percent Range

97.5% min. (HPLC)

Packaging

Glass bottle

Quantity

1 g

Merck Index

15, 4824

Specific Rotation Condition

+150° (156°C c=1,dioxane)

Specific Rotation

+ 150

Solubility Information

Solubility in water: 0.28g/L (25°C). Other solubilities: soluble in sulfuric acid,partially soluble in alcohol and propylene glycol,soluble in dioxane; sol (g/l) (25°C): chcl3 1.6;,ether 0.35; etoh 15; meoh 6.2; acetone 9.3;,propylene glycol 1

Formula Weight

362.47

Percent Purity

98%

Physical Form

Powder

Chemical Name or Material

Hydrocortisone

Hazard Category

GHS Signal Word: Danger

Hazard Statement

GHS H Statement
May damage the unborn child.
Suspected of damaging fertility.

Precautionary Statement

GHS P Statement
Obtain special instructions before use.

EINECSNumber

200-020-1

SDS

Hazard Category

GHS Signal Word: Danger

Hazard Statement

GHS H Statement
May damage the unborn child.
Suspected of damaging fertility.

Precautionary Statement

GHS P Statement
Obtain special instructions before use.

EINECSNumber

200-020-1

SDS

RUO – Research Use Only