Hydroxyurea, 98%, Thermo Scientific Chemicals

Hydroxyurea, 98%, CAS # 127-07-1, is a compound with antineoplastic, immunomodulatory, radical scavenger, and antimitotic activities. It shows inhibitory activity against nucleic acid synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Hydroxyurea is a member of the class of urea that shows antineoplastic, immunomodulatory, radical scavenger, and antimitotic activities.

• It has inhibitory activity against nucleic acid synthesis.

• It also inhibits ribonucleoside diphosphate reductase, an enzyme necessary to convert ribonucleoside diphosphate into deoxyribonucleoside diphosphate, preventing cells from leaving the G1/S phase of the cell cycle

Applications

• Hydroxyurea has an anti-retroviral activity, inhibiting human immunodeficiency virus type 1 (HIV-1) DNA synthesis in peripheral blood lymphocytes, decreasing the amount of intracellular deoxynucleotides

• This compound also has a radio sensitizing activity, maintaining cells in the radiation-sensitive G1 cell cycle phase and, consequently, interfering with DNA repair

• It has been used for cell cycle synchronization in human breast carcinoma cells

• This compound presents inhibitory activity in cell adhesion and motility assay in ccRCC Caki (HTB-47) and CD9 knockdown cells

Chemical Identifiers

CAS

127-07-1

Molecular Formula

CH₄N₂O₂

Molecular Weight (g/mol)

76.04

MDL Number

MFCD00007943

InChI Key

VSNHCAURESNICA-UHFFFAOYSA-N

Synonym

hydroxycarbamide, n-hydroxyurea, hydrea, 1-hydroxyurea, oxyurea, carbamoyl oxime, biosupressin, hydroxycarbamine, onco-carbide, carbamohydroxamic acid

PubChem CID

3657

ChEBI

CHEBI:44423

IUPAC Name

hydroxyurea

SMILES

C(=O)(N)NO

Melting Point

142°C to 146°C

Color

White

Loss on Drying

1% max. (1 g, 60°C) (< 0.7 kPa)

Infrared Spectrum

Authentic

Assay Percent Range

97.5% min. (on dried substance) (Iodometry)

Packaging

Glass bottle

Linear Formula

HONHCONH₂

Quantity

100 g

Beilstein

03, 95

Merck Index

15, 4888

Solubility Information

Solubility in water: freely soluble. Other solubilities: freely soluble in hot alcohol

Formula Weight

76.04

Percent Purity

98%

Physical Form

Crystalline Powder

Chemical Name or Material

Hydroxyurea

Hazard Category

GHS Signal Word: Danger

Hazard Statement

GHS H Statement:
May cause genetic defects.
May damage the unborn child.

Precautionary Statement

GHS P Statement:
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

EINECSNumber

204-821-7

SDS

Hazard Category

GHS Signal Word: Danger

Hazard Statement

GHS H Statement:
May cause genetic defects.
May damage the unborn child.

Precautionary Statement

GHS P Statement:
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

EINECSNumber

204-821-7

SDS

RUO – Research Use Only