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  7. IKK 16, Tocris Bioscience™

IKK 16, Tocris Bioscience™

Catalog No. p-4784032 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Selective inhibitor of IKK

Selective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC50 values are 1.0, 0.5, 0.3 and 0.3 μM respectively). Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

Chemical Identifiers

CAS 1186195-62-9
Molecular Formula C28H30ClN5OS
Molecular Weight (g/mol) 520.092
InChI Key XFVDIVQCZWDBCW-UHFFFAOYSA-N
Synonym ikk 16, ikk-16, ikk-16 hcl, 4-1-benzothiophen-2-yl-n-4-4-pyrrolidin-1-yl piperidine-1-carbonyl phenyl pyrimidin-2-amine hydrochloride
PubChem CID 56972179
IUPAC Name [4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone;hydrochloride
SMILES C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl

Specifications

Quantity 10 mg
Formula Weight 520.09
Percent Purity >98%
Chemical Name or Material IKK 16

Safety and Handling

Recommended Storage Desiccate at -20°C
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