IL-17A Mouse, anti-Human, RB780, Clone: N49-653, BD Horizon™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 568766

Catalog No. BDB568766

Description

Human IL-17A, also known as IL-17, is a proinflammatory cytokine that is encoded by the IL17A gene in chromosome 6. IL-17A is produced as a disulfide-linked homodimer comprised of two mature 136-amino acid polypeptides. It is a member of the IL-17 family of structurally related cytokines, designated IL-17A through IL-17F. Activated memory T cells, especially Th17 cells (specialized IL-17A-producing CD4+ T cells distinct from Th1 and Th2 cells) produce IL-17 and provide protective immunity against pathogens. Activated CD8+ T cells, γδT cells, NK cells and neutrophils can also be activated to produce IL-17A. IL-17A binds to and exerts its biological activity through IL-17 receptors (IL-17R) that are expressed by a variety of target cells including fibroblasts, epithelial and endothelial cells, monocytes/macrophages and mast cells. The ubiquitous IL-17R expression pattern may explain the broad tissue responsiveness to IL-17. IL-17 induces stromal cells to secrete cytokines and chemokines involved in inflammatory and hematopoietic processes. For example, IL-17 induces fibroblasts to produce IL-6, IL-8, G-CSF and express increased surface ICAM-1. The N49-653 antibody reacts with human IL-17A.

Specifications

• Antigen: IL-17A
• Clone: N49-653
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide
• Immunogen: Human IL-17A Recombinant Protein
• Regulatory Status: RUO
• Gene ID (Entrez): 3605
• Content And Storage: Refrigerate (2°C to 8°C)

• Applications: Flow Cytometry
• Conjugate: RB780
• Host Species: Mouse
• Quantity: 25 Tests
• Primary or Secondary: Secondary
• Target Species: Human
• Isotype: IgG1 κ