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Indirubin-3'-oxime, Tocris Bioscience™

Catalog No. 181350 Shop All R&D Systems Products
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GSK-3β inhibitor. Also inhibits other protein kinases

Inhibitor of GSK-3β (IC50 = 190 nM) and cyclin dependent kinases (cdks; IC50 values are 0.05, 0.18 and 0.25-0.5 βM for cdk9, cdk1 and cdk2, respectively). Also reported to inhibit AMPK, LCK and SGK. Inhibits cdk5- and GSK-3β-mediated tau phosphorylation. Induces cell cycle arrest and inhibits cell proliferation.

Chemical Identifiers

CAS

160807-49-8

Molecular Formula

C16H11N3O2

Molecular Weight (g/mol)

277.28

MDL Number

MFCD02683594

InChI Key

LDEWQRSYYHTQRA-UHFFFAOYSA-N

Synonym

indirubin-3'-monoxime, indirubin-3'-oxime, indirubin-3-oxime, indirubin-3monoxime, indirubin-3'-monooxime, indirubin-3-monoxime, 3-3-hydroxyamino-1h-indol-2-yl indol-2-one, indirubin-3′-monoxime, z-1h,1'h-2,3' biindolylidene-3,2'-dione-3-oxime, 3-1,3-dihydro-3-hydroxyimino-2h-indol-2-ylidene-1,3-dihydro-2h-indol-2-one

PubChem CID

5326739

IUPAC Name

3-(hydroxyamino)-1H,2'H-[2,3'-biindol]-2'-one

SMILES

ONC1=C(NC2=CC=CC=C12)C1=C2C=CC=CC2=NC1=O

Specifications

Quantity

50 mg

Formula Weight

277.28

Percent Purity

>99%

Chemical Name or Material

Indirubin-3'-oxime

Recommended Storage

Store at Room Temperature
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