Thermo Scientific Chemicals Ionomycin, 96%

Highly selective and potent calcium ionophore

Ionomycin free acid is a beneficial tool in research to raise intracellular calcium levels. Also this antibiotic can be used to study the calcium transport across the plasma membrane. It has been shown to induce central demyelination , inhibit adrenal bovine TREK-1 channels , and to regulate cell division of mature human B cells . It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochondrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Chemical Identifiers

CAS

56092-81-0

Molecular Formula

C41H72O9

Quantity

1 mg

Description

Colorless

Content And Storage

-30°C to -10°C

For Use With (Application)

Highly selective and potent calcium ionophore

Formula Weight

709.02

Odor

Alcohol-like

Product Type

Ionomycin

Form

Solution in ethanol

Beilstein

3642126

InChI Key

PGHMRUGBZOYCAA-OJFQOPKISA-N

SMILES

C[C@H](CCC(O)=O)C[C@H](C)C[C@H](C)C(=O)\C=C(/O)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)CC1CC[C@](C)(O1)C1CC[C@](C)(O1)[C@@H](C)O

IUPAC Name

(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-trihydroxy-22-[(2S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl-[2,2'-bioxolan]-5-yl]-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid

Molecular Weight (g/mol)

709.02

Assay

98%

Recommended Storage

Store at -20°C

SDS

Recommended Storage

Store at -20°C

SDS

RUO – Research Use Only