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IOX 1, Tocris Bioscience™

Catalog No. p-4817116 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Histone demethylase inhibitor; cell permeable

IOX 1 is a histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; it inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. IOX 1 suppresses IL-17 expression in mouse and human CD4+ T cells by targeting TET2. It also reduces infiltration of Th17 cells in an in vivo model of intraocular inflammation.

Chemical Identifiers

CAS 5852-78-8
Molecular Formula C10H7NO3
Molecular Weight (g/mol) 189.17
InChI Key JGRPKOGHYBAVMW-UHFFFAOYSA-N
PubChem CID 459617
IUPAC Name 8-hydroxyquinoline-5-carboxylic acid
SMILES C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O

Specifications

Quantity 10 mg
Synonym iox1, 8-hydroxy-5-quinolinecarboxylic acid, 5-carboxy-8-hydroxyquinoline, iox 1, unii-jm015yqc1c, iox-1, 5-carboxy-8hq, 5-quinolinecarboxylic acid, 8-hydroxy, jm015yqc1c, 4bio
Formula Weight 189.17
Percent Purity >99%
Chemical Name or Material IOX 1

Safety and Handling

Recommended Storage Store at +4°C
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