JNJ 10397049, Tocris Bioscience™

Selective OX2 receptor antagonist

Selective OX2 receptor antagonist (pIC50 = 7.4 for chimeric OX2 receptors; pKB values are 5.9 and 8.5 for OX1 and OX2 receptors respectively). Shows no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. Achieves high level of OX2 receptor occupancy in the rat brain; exhibits sleep-promoting effects in rats.

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Chemical Identifiers

CAS

708275-58-5

Molecular Formula

C19H20Br2N2O3

Molecular Weight (g/mol)

484.188

InChI Key

RBKIJGLHFFQHBE-IRXDYDNUSA-N

Synonym

unii-1b419p24av, n-2,4-dibromophenyl-n'-4s,5s-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl-urea, 1-2,4-dibromophenyl-3-4s,5s-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl urea, d01sul, compound 9 pmid: 15261275, 1-2,4-dibromophenyl-3-4s,5s-2,2-dimethyl-4-phenyl-1,3 dioxan-5-yl urea, urea, n-2,4-dibromophenyl-n'-4s,5s-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl, 3-2,4-dibromophenyl-1-4s,5s-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl urea

PubChem CID

9869934

IUPAC Name

1-(2,4-dibromophenyl)-3-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]urea

SMILES

CC1(OCC(C(O1)C2=CC=CC=C2)NC(=O)NC3=C(C=C(C=C3)Br)Br)C

Quantity

50 mg

Formula Weight

484.18

Percent Purity

>99%

Chemical Name or Material

JNJ 10397049

Recommended Storage

Store at +4°C

Recommended Storage

Store at +4°C