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JNJ 303, Tocris Bioscience™

Catalog No. 389950 Shop All R&D Systems Products
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This item is not returnable. View return policy

Potent and selective IKs blocker

Potent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).

Chemical Identifiers

CAS

878489-28-2

Molecular Formula

C21H29ClN2O4S

Molecular Weight (g/mol)

440.983

InChI Key

OSGIRCJRKSAODN-DJASPMHUSA-N

Synonym

2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13, 7]dec-2-yl]-propanamide

PubChem CID

11575823

IUPAC Name

2-(4-chlorophenoxy)-N-[(1R,3S)-5-(methanesulfonamido)-2-adamantyl]-2-methylpropanamide

SMILES

CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)NS(=O)(=O)C)OC4=CC=C(C=C4)Cl

Specifications

Quantity

50 mg

Formula Weight

440.98

Percent Purity

>98%

Chemical Name or Material

JNJ 303

Recommended Storage

Store at +4°C
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