JZP 361, >99%, Tocris Bioscience™

Description

Potent and selective reversible MAGL inhibitor

Potent and selective reversible MAGL inhibitor (IC50 = 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC50 values are 1.79 and 7.24 μM, respectively). Displays affinity for H1 receptors (pA2 = 6.81). Exhibits no activity at cannabinoid receptors at 10 μM.

Specifications

• Chemical Name or Material: [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-
• CAS: 1680193-80-9
• Purity Grade Notes: >99%
• Molecular Formula: C22H20ClN5O
• Linear Formula: C₂₂H₂₀ClN₅O
• Quantity: 10mg
• Synonym: 4-8-chloro-5,6-dihydro-11h-benzo 5,6 cyclohepta 1,2-b pyridin-11-ylidene-1-piperidinyl 1h-1,2,4-triazol-1-yl methanone
• Solubility Information: Soluble to 100mM in DMSO and to 20mM in ethanol
• InChI Key: GAVZCGTYRWKKDV-UHFFFAOYSA-N
• SMILES: C1CC2=C(C=CC(=C2)Cl)C(=C3CCN(CC3)C(=O)N4C=NC=N4)C5=C1C=CC=N5
• IUPAC Name: [4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)piperidin-1-yl]-(1,2,4-triazol-1-yl)methanone
• Molecular Weight (g/mol): 405.886
• PubChem CID: 102596130
• Formula Weight: 405.88