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K 252a, Tocris Bioscience™

Catalog No. 1683200U Shop All R&D Systems Products
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Quantity:
200 μg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Protein kinase inhibitor

Non-selective protein kinase inhibitor; analog of staurosporine (Cat.No. 1285). Inhibits PKC (IC50 = 32.9 nM), Ca2+/calmodulin-stimulated phosphodiesterases (IC50 = 1.3 - 2.9 μM), MLCK (Ki = 20 nM) and receptor tyrosine kinases. Inhibits the oncogenic properties of MET; prevents autophosphorylation and activation of downstream effectors (MAPK, Akt).

Chemical Identifiers

CAS 99533-80-9
Molecular Formula C27H21N3O5
Molecular Weight (g/mol) 467.481
InChI Key KOZFSFOOLUUIGY-PNKDDGGRSA-N
Synonym (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
PubChem CID 98053103
SMILES CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O

Specifications

Quantity 200 μg
Formula Weight 467.48
Percent Purity >98%
Chemical Name or Material K 252a

Safety and Handling

Recommended Storage Desiccate at -20°C
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