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KN-93, Tocris Bioscience™

Catalog No. 12781 Shop All R&D Systems Products
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Quantity:
1 mg
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Description

CaM kinase II inhibitor; also K+ channel blocker (KV)

Potent, cell permeable inhibitor of CaM kinase II (IC50 = 0.37 μM). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC50 = 307 nM for KV1.5) and abolishes IKr in ventricular myocytes (IC50 = 102.6 nM) independently of CaM kinase II inhibition.

Water soluble form and Negative Control also available.

Chemical Identifiers

CAS 139298-40-1
Molecular Formula C26H29ClN2O4S
Molecular Weight (g/mol) 501.038
InChI Key LLLQTDSSHZREGW-AATRIKPKSA-N
Synonym methoxybenzene-sulfonamide, insolution kn-93, e-n-2-3-4-chlorophenyl allyl methyl amino methyl phenyl-n-2-hydroxyethyl-4-methoxybenzenesulfonamide, 2-n-2-hydroxyethyl-n-4-methoxybenzenesulfonyl amino-n-4-chlorocinnamyl-n-methylbenzylamine, benzenesulfonamide, n-2-3-4-chlorophenyl-2-propenyl methylamino methyl phenyl-n-2-hydroxyethyl-4-methoxy, n-2-3-4-chlorophenyl-2-propenyl methylamino methyl phenyl-n-2-hydroxyethyl-4-methoxybenzenesulfonamide, n-2-2e-3-4-chlorophenyl prop-2-en-1-yl methyl amino methyl phenyl-n-2-hydroxyethyl-4-methoxybenzenesulfonamide, kn-93 free base
PubChem CID 5312122
IUPAC Name N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
SMILES CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC

Specifications

Quantity 1 mg
Formula Weight 501.04
Percent Purity >98%
Chemical Name or Material KN-93

Safety and Handling

Recommended Storage Store at +4°C
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