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KU 0060648, Tocris Bioscience™

Catalog No. p-4816713 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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Description

Dual DNA-PK and PI 3-K inhibitor

Dual PI 3-K and DNA-PK inhibitor (IC50 values are <0.1, 0.5, 4 and 19 nM for PI 3-Kδ, PI 3-Kβ, PI 3-Kα and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency ∽2 to 4-fold, and decreases nonhomologous end-joining (NHEJ) frequency ∽40%; maximum effect seen at 250 nM.

Chemical Identifiers

CAS 881375-00-4
Molecular Formula C33H34N4O4S
Molecular Weight (g/mol) 582.719
InChI Key AATCBLYHOUOCTO-UHFFFAOYSA-N
Synonym 2-4-ethylpiperazin-1-yl-n-4-2-morpholino-4-oxo-4h-chromen-8-yl dibenzo b,d thiophen-1-yl acetamide, 2-4-ethylpiperazin-1-yl-n-4-2-morpholin-4-yl-4-oxochromen-8-yl dibenzothiophen-1-yl acetamide, d0r0tw, ku hplc, 2-4-ethylpiperazin-1-yl-n-6-2-morpholin-4-yl-4-oxo-4h-chromen-8-yl-8-thiatricyclo 7.4.0.0?,? trideca-1 13 ,2,4,6,9,11-hexaen-3-yl acetamide, 2-4-ethylpiperazin-1-yl-n-6-2-morpholin-4-yl-4-oxochromen-8-yl-8-thiatricyclo 7.4.0.0 2 ,? trideca-1 9 ,2 7 ,3,5,10,12-hexaen-3-yl acetamide, 4-ethyl-n-4-2-4-morpholinyl-4-oxo-4h-1-benzopyran-8-yl-1-dibenzothienyl-1-piperazineacetamide, n-4-2-morpholino-4-oxo-4h-1-benzopyran-8-yl dibenzothiophene-1-yl-4-ethylpiperazine-1-acetamide
PubChem CID 11964036
IUPAC Name 2-(4-ethylpiperazin-1-yl)-N-[4-(2-morpholin-4-yl-4-oxochromen-8-yl)dibenzothiophen-1-yl]acetamide
SMILES CCN1CCN(CC1)CC(=O)NC2=C3C4=CC=CC=C4SC3=C(C=C2)C5=CC=CC6=C5OC(=CC6=O)N7CCOCC7

Specifications

Quantity 10 mg
Formula Weight 582.71
Percent Purity >97%
Chemical Name or Material KU 0060648

Safety and Handling

Recommended Storage Store at -20°C
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