L 006235, Tocris Bioscience™

Potent cathepsin K inhibitor

Potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence.

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Chemical Identifiers

CAS

294623-49-7

Molecular Formula

C24H30N6O2S

Molecular Weight (g/mol)

466.604

InChI Key

FIVYCSWOCXEWSE-UHFFFAOYSA-N

Synonym

n-1-cyanomethyl carbamoyl cyclohexyl-4-2-4-methylpiperazin-1-yl thiazol-4-yl benzamide, n-1-cyanomethyl amino carbonyl cyclohexyl-4-2-4-methyl-1-piperazinyl-4-thiazolyl benzamide, d0z0pr, basic piperazine-containing compound, 1, n-1-cyanomethyl carbamoyl cyclohexyl-4-2-4-methylpiperazin-1-yl-1,3-thiazol-4-yl benzamide

PubChem CID

9912381

IUPAC Name

N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide

SMILES

CN1CCN(CC1)C2=NC(=CS2)C3=CC=C(C=C3)C(=O)NC4(CCCCC4)C(=O)NCC#N

Quantity

50 mg

Formula Weight

466.6

Percent Purity

>98%

Chemical Name or Material

L 006235

Recommended Storage

Store at +4°C

Recommended Storage

Store at +4°C