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L-161,982, Tocris Bioscience™

Catalog No. 251410 Shop All R&D Systems Products
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Quantity:
10 mg
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This item is not returnable. View return policy

Description

Selective EP4 receptor antagonist

L-161,982 is an EP4 receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively). Suppresses PGE2-induced bone formation in rats and prevents the nociceptive response induced by Misoprostol (Cat. No. 2297) in formalin-injected mice.

Chemical Identifiers

CAS 147776-06-5
Molecular Formula C32H29F3N4O4S2
Molecular Weight (g/mol) 654.723
InChI Key MMDNKTXNUZFVKD-UHFFFAOYSA-N
Synonym chembl97688, 4-3-butyl-5-oxo-1-2-trifluoromethyl-phenyl-1,5-dihydro-1,2,4 triazol-4-ylmethyl-biphenyl-2-sulfonic acid 3-methyl-thiophene-2-carbonyl-amide; compound with dichloro-methane, n-4'-3-butyl-1,5-dihydro-5-oxo-1-2-trifluoromethyl phenyl-4h-1,2,4-triazol-4-yl methyl 1,1'-biphenyl-2-yl sulfonyl-3-methyl-2-thiophenecarboxamide
PubChem CID 9961192
IUPAC Name N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide
SMILES CCCCC1=NN(C(=O)N1CC2=CC=C(C=C2)C3=CC=CC=C3S(=O)(=O)NC(=O)C4=C(C=CS4)C)C5=CC=CC=C5C(F)(F)F

Specifications

Quantity 10 mg
Formula Weight 654.72
Percent Purity >99%
Chemical Name or Material L-161, 982

Safety and Handling

Recommended Storage Desiccate at +4°C
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