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  8. 241010

L-371,257, Tocris Bioscience™

Catalog No. 241010 Shop All R&D Systems Products
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Quantity:
10 mg
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This item is not returnable. View return policy

Description

Potent and selective oxytocin receptor antagonist

Potent, high affinity human oxytocin (OT) receptor antagonist (Ki = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V1a and V2. Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Decreases length of U-87MG cell projections induced by retinoic acid (Cat.No.0695). Orally active.

Chemical Identifiers

CAS 162042-44-6
Molecular Formula C28H33N3O6
Molecular Weight (g/mol) 507.587
InChI Key WDERJSQJYIJOPD-UHFFFAOYSA-N
Synonym chembl24781, 1-1-4-1-acetylpiperidin-4-yl oxy-2-methoxybenzoyl piperidin-4-yl-4h-3,1-benzoxazin-2-one, d08pac, 1-4-1-acetyl-4-piperidinyl oxy-2-methoxybenzoyl-4-2-oxo-2h-3,1-benzoxazin-1 4h-yl piperidine, 1-1-4-1-acetylpiperidin-4-yloxy-2-methoxybenzoyl piperidin-4-yl-1h-benzo d 1,3 oxazin-2 4h-one, 1-1-4-1-acetyl-piperidin-4-yloxy-2-methoxy-benzoyl-piperidin-4-yl-1,4-dihydro-benzo d 1,3 oxazin-2-one
PubChem CID 6918320
IUPAC Name 1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one
SMILES CC(=O)N1CCC(CC1)OC2=CC(=C(C=C2)C(=O)N3CCC(CC3)N4C5=CC=CC=C5COC4=O)OC

Specifications

Quantity 10 mg
Formula Weight 507.59
Percent Purity >99%
Chemical Name or Material L-371, 257

Safety and Handling

Recommended Storage Store at Room Temperature
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