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  7. L-838,417, Tocris Bioscience™

L-838,417, Tocris Bioscience™

Catalog No. p-4784094 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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Description

GABAA partial agonist; displays subtype selectivity

Subtype-selective GABAA receptor partial agonist. Selectively binds to α1, α2, α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo.

Chemical Identifiers

CAS 286456-42-6
Molecular Formula C19H19F2N7O
Molecular Weight (g/mol) 399.41
MDL Number MFCD08690609
InChI Key BQDUNOMMYOKHEP-UHFFFAOYSA-N
PubChem CID 9908880
IUPAC Name 5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1H-1,2,4-triazole
SMILES CN1N=CN=C1COC1=NN2C(C=C1C(C)(C)C)=NN=C2C1=C(F)C=CC(F)=C1

Specifications

Quantity 10 mg
Synonym unii-8czo0970g3, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4-triazolo 4,3-b pyridazine, 7-tert-butyl-3-2,5-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4 triazolo 4,3-b pyridazine, 5-7-tert-butyl-3-2,5-difluorophenyl-1,2,4 triazolo 4,3-b pyridazin-6-yl oxy methyl-1-methyl-1,2,4-triazole, 1,2,4-triazolo 4,3-b pyridazine, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, l hplc, 1,2,4-triazolo 4,3-b pyridazine,3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-2-methyl-2h-1,2,4-triazol-3-ylmethoxy-1,2,4-triazolo 4,3-b pyridazine, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4,-triazol-5-yl methoxy-1,2,4-triazolo 4,3-b pyridazine
Formula Weight 399.4
Percent Purity >98%
Chemical Name or Material L-838, 417

Safety and Handling

Recommended Storage Store at +4°C
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