L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals

L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase

• It has tumoricidal activity

Applications

• L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase

• It can be used in anti-tumor studies

• It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins

• It can also inhibit production of pro-inflammatory cytokines

Chemical Identifiers

CAS

133073-73-1

Molecular Formula

C20H22N8O5

Molecular Weight (g/mol)

454.45

MDL Number

MFCD00150847

InChI Key

FBOZXECLQNJBKD-UGPWUYPHNA-N

Synonym

l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrate

PubChem CID

45157423

IUPAC Name

(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate

SMILES

CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

Melting Point

195°C

Color

Yellow to Orange

Infrared Spectrum

Authentic

Assay Percent Range

98.5% min. (HPLC)

Packaging

Glass Bottle

Quantity

500 mg

Merck Index

14, 5985

Specific Rotation Condition

+ 21.50 (20.00°C c=1,14g/l Na2CO3)

Specific Rotation

+ 21.5

Solubility Information

Solubility in water: insoluble in water. Other solubilities: insoluble in alcohol,chloroform,ether,slightly soluble in dilute hydrochloric acid,soluble in dilute solutions of alkali hydroxides a

Formula Weight

454.44

Percent Purity

99%

Physical Form

Crystalline Powder

Chemical Name or Material

L(+)-Amethopterin hydrate

Hazard Category

GHS Signal Word: Danger

Hazard Statement

GHS H Statement:
Toxic if swallowed.
May cause genetic defects.
May damage the unborn child.

Precautionary Statement

GHS P Statement:
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

SDS

Hazard Category

GHS Signal Word: Danger

Hazard Statement

GHS H Statement:
Toxic if swallowed.
May cause genetic defects.
May damage the unborn child.

Precautionary Statement

GHS P Statement:
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

SDS

RUO – Research Use Only