Lovastatin, 97%, Thermo Scientific Chemicals

Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

Solubility
Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), methanol, chloroform, acetone, acetonitrile, DMF, and water (0.4 µg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.

Chemical Identifiers

CAS

75330-75-5

Molecular Formula

C24H36O5

Molecular Weight (g/mol)

404.55

MDL Number

MFCD00072164

InChI Key

PCZOHLXUXFIOCF-BXMDZJJMSA-N

Synonym

lovastatin, mevinolin, mevacor, monacolin k, lovalip, altoprev, lovalord, mevinacor, nergadan, 6alpha-methylcompactin

PubChem CID

53232

ChEBI

CHEBI:40303

IUPAC Name

(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate

SMILES

CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

Melting Point

175°C

Quantity

5 g

Solubility Information

Soluble in DMSO (10mg/ml),ethanol (10mg/ml),methanol,chloroform,acetone,acetonitrile,DMF,and water (0.4 μg/ml).

Formula Weight

404.56

Percent Purity

97%

Chemical Name or Material

Lovastatin

Hazard Category

H317-H351-H361d

Hazard Statement

GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

Precautionary Statement

P201-P202-P261-P272-P280g-P281-P302+P352-P308+P313-P333+P313-P363-P501c

RTECSNumber

EK7907000

TSCA

No

Recommended Storage

Ambient temperatures

SDS

Hazard Category

H317-H351-H361d

Hazard Statement

GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

Precautionary Statement

P201-P202-P261-P272-P280g-P281-P302+P352-P308+P313-P333+P313-P363-P501c

RTECSNumber

EK7907000

TSCA

No

Recommended Storage

Ambient temperatures

SDS

RUO – Research Use Only