Thermo Scientific Chemicals Lovastatin, 98%

Lovastatin, CAS # 75330-75-5, is a cholesterol lowering compound and inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Applications

• It blocks product ion of mevalonate, a critical compound in the production of cholesterol and isoprenoids

• It can increase cellular resistance to anticancer agents such as doxorubicin • It can induce apoptosis in myeloma cells

• It can cause cell cycle arrest in G1 and G2/M phase

• It also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF

Chemical Identifiers

CAS

75330-75-5

Molecular Formula

C24H36O5

Molecular Weight (g/mol)

404.55

MDL Number

MFCD00072164

InChI Key

PCZOHLXUXFIOCF-BXMDZJJMSA-N

Synonym

lovastatin, mevinolin, mevacor, monacolin k, lovalip, altoprev, lovalord, mevinacor, nergadan, 6alpha-methylcompactin

PubChem CID

53232

ChEBI

CHEBI:40303

IUPAC Name

[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate

SMILES

CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12

Melting Point

175.0°C

Infrared Spectrum

Authentic

Assay Percent Range

97.5% min. (HPLC)

Quantity

100 g

Solubility Information

Solubility in water: insoluble. Other solubilities: less soluble in ethanol, soluble in chloroform and acetone

Formula Weight

404.54

Percent Purity

98%

Chemical Name or Material

Lovastatin

Hazard Category

GHS Signal Word: Warning

Hazard Statement

GHS H Statement
May cause an allergic skin reaction.
Suspected of causing cancer.
Suspected of damaging the unborn child.

Precautionary Statement

GHS P Statement
Wear protective gloves/protective clothing.
IF ON SKIN: Wash with plenty of soap and water.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.

SDS

Hazard Category

GHS Signal Word: Warning

Hazard Statement

GHS H Statement
May cause an allergic skin reaction.
Suspected of causing cancer.
Suspected of damaging the unborn child.

Precautionary Statement

GHS P Statement
Wear protective gloves/protective clothing.
IF ON SKIN: Wash with plenty of soap and water.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.

SDS

RUO – Research Use Only