LY 344864 hydrochloride, Tocris Bioscience™

Description

Potent and selective 5-HT1F agonist

Potent, selective 5-HT1F receptor agonist (EC50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT2A and 5-HT7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

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Specifications

Chemical Identifiers

• CAS: 1217756-94-9
• Molecular Formula: C21H23ClFN3O
• Molecular Weight (g/mol): 387.883
• InChI Key: OKUHLSYESBLBCP-PKLMIRHRSA-N
• Synonym: r-n-3-dimethylamino-2,3,4,9-tetrahydro-1h-carbazol-6-yl-4-fluorobenzamide hydrochloride, ly-344864 hydrochloride, ly 344864 hydrochloride, n-6r-6-dimethylamino-6,7,8,9-tetrahydro-5h-carbazol-3-yl-4-fluorobenzamide hydrochloride, n-3r-3-dimethylamino-2,3,4,9-tetrahydro-1h-carbazol-6-yl-4-fluoro-benzamide hcl, n-3r-3-dimethylamino-2,3,4,9-tetrahydro-1h-carbazol-6-yl-4-fluorobenzamidehydrochloride
• PubChem CID: 56972176
• IUPAC Name: N-[(6R)-6-(dimethylamino)-6,7,8,9-tetrahydro-5H-carbazol-3-yl]-4-fluorobenzamide;hydrochloride
• SMILES: CN(C)C1CCC2=C(C1)C3=C(N2)C=CC(=C3)NC(=O)C4=CC=C(C=C4)F.Cl

• Quantity: 10 mg
• Formula Weight: 387.88
• Percent Purity: >99%
• Chemical Name or Material: LY 344864 hydrochloride

Safety and Handling

Recommended Storage

Store at +4°C