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LY 487379 hydrochloride, Tocris Bioscience™

Catalog No. 328350 Shop All R&D Systems Products
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Selective positive allosteric modulator of mGlu2 receptors

Positive allosteric modulator selective for mGlu2 receptors. Potentiates glutamate-stimulated [35S]GTPγS binding (EC50 values are 1.7 and > 10 μM for mGlu2 and mGlu3 receptors respectively). Devoid of any activity at mGlu5 and mGlu7 receptors. Promotes cognitive flexibility in a rat model.

Chemical Identifiers

CAS

353229-59-1

Molecular Formula

C21H20ClF3N2O4S

Molecular Weight (g/mol)

488.906

InChI Key

LPWFRDWTOKLHJC-UHFFFAOYSA-N

Synonym

ly 487379 hydrochloride, ly-487379 hydrochloride, 2,2,2-trifluoro-n-4-2-methoxyphenoxy phenyl-n-3-pyridinylmethyl ethanesulfonamide hydrochloride, 2,2,2-trifluoro-n-4-2-methoxyphenoxy phenyl-n-pyridin-3-ylmethyl ethanesulfonamide hydrochloride, ly-487379 hydrochloride hplc, 2,2,2-trifluoro-n-4-2-methoxyphenoxy phenyl-n-pyridin-3-yl methyl ethane-1-sulfonamide-hydrogen chloride 1/1, n-4-2-methoxyphenoxy phenyl-n-2,2,2-trifluoroethylsulfonyl pyrid-3-ylmethylamine hydrochloride

PubChem CID

56972206

IUPAC Name

2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(pyridin-3-ylmethyl)ethanesulfonamide;hydrochloride

SMILES

COC1=CC=CC=C1OC2=CC=C(C=C2)N(CC3=CN=CC=C3)S(=O)(=O)CC(F)(F)F.Cl

Specifications

Quantity

50 mg

Formula Weight

488.91

Percent Purity

>99%

Chemical Name or Material

LY 487379 hydrochloride

Recommended Storage

Store at -20°C
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