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AdipoGen Manumycin A
SDP

Supplier:  AdipoGen BVT0091M005

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Chemical. CAS 52665-74-4. Formula C31H38N2O7. MW 550.6. Isolated from Streptomyces parvulus. Antibiotic. Apoptosis and endoplasmic reticulum stress-mediated cell death inducer. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor IC50 = 30 nM. Does not affect geranylgeranyltransferase IC50 = 180 µM. Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes 19 µM. Targets protein phosphatase 1alpha PP1alpha and reduces hydrogen peroxide. Corrects aberrant splicing of the muscle chloride channel Clcn1 in myotonic dystrophy type 1 DM1. Shows potential anti-inflammatory activity.

Catalog No. 50-256-2108


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