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AdipoGen Metformin . HCl (1 g)
Supplier: AdipoGen AGCR13689G001
Metformin . HCl (1 g), Adipogen Life Sciences. Chemical. CAS: 1115-70-4. Formula: C4H11N5 . HCl. MW: 129.2 . 36.5. . AMPK activator. Useful agent for immunometabolism research. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation. Mitochondrial electron transport chin complex I inhibitor, reducing mitochondrial reactive oxygen species (ROS). Antidiabetic and anti-hyperglycemic agent that reduces blood glucose levels, improves insulin sensitivity and decreases insulin resistance. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated in part by activation of the LKB1-AMPK pathway. Used as weight-loss agent in obesity and as insulin sensitizer in nonalcoholic fatty liver disease (NAFLD). Leptin sensitizer to mediate the weight-loss effect in the brain. Targets brown adipose tissue (BAT) in vivo and reduces oxygen consumption.
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