Methotrexate disodium salt, 98.5%, Thermo Scientific Chemicals

Methotrexate disodium salt, CAS # 7413-34-5, is the sodium salt of methotrexate that shows antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities.

Inhibits the metabolism of folic acid

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Methotrexate disodium salt is an organic sodium salt derived from methotrexate with antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities

• It acts as an enzyme inhibitor of dihydrofolate reductase

• It binds to and inhibits purine nucleotide and thymidylate synthesis, leading to the inhibition of DNA and RNA synthesis. Because of this mechanism of action, the methotrexate disodium salt is defined as a nucleic acid synthesis inhibitor

Application

• Methotrexate disodium salt is a folic acid antagonist with the ability to inhibit folic acid metabolism

• In vitro studies demonstrated that methotrexate disodium salt has potent activity against pyrimethamine-resistant Plasmodium vivax malaria parasites

• This compound has been used in chimeric polymersomes in order to investigate its effect in lung tumor xenografts in mice

Chemical Identifiers

CAS

7413-34-5

Molecular Formula

C20H20N8Na2O5

Molecular Weight (g/mol)

498.411

MDL Number

MFCD00274560

InChI Key

DASQOOZCTWOQPA-GXKRWWSZSA-L

Synonym

methotrexate disodium salt, sodium methotrexate, ledertrexate, methotrexate sodium, mtx disodium, methotrexate disodium, unii-3ig1e710zn, trexall, mexate, methotrexate lpf

PubChem CID

11329481

ChEBI

CHEBI:50679

IUPAC Name

disodium;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate

SMILES

CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

Color

Yellow

Boiling Point

823°C

Quantity

250 mg

UN Number

UN2811

Sensitivity

Hygroscopic

Solubility Information

Soluble in water

Formula Weight

498.4

Percent Purity

98.5%

Physical Form

Powder

Chemical Name or Material

Methotrexate disodium salt

Hazard Category

H301-H315-H319

Hazard Statement

GHS H Statement
H301
Toxic if swallowed.

Precautionary Statement

P264b-P270-P280-P301+P310-P302+P352-P305+P351+P338-P330-P332+P313-P362-P501c

DOTInformation

Hazard Class: 6.1

EINECSNumber

231-022-0

RTECSNumber

MA1232000

TSCA

No

storageNote1

2° to 8°C

Recommended Storage

Keep cold; Store under Argon

SDS

Hazard Category

H301-H315-H319

Hazard Statement

GHS H Statement
H301
Toxic if swallowed.

Precautionary Statement

P264b-P270-P280-P301+P310-P302+P352-P305+P351+P338-P330-P332+P313-P362-P501c

DOTInformation

Hazard Class: 6.1

EINECSNumber

231-022-0

RTECSNumber

MA1232000

TSCA

No

storageNote1

2° to 8°C

Recommended Storage

Keep cold; Store under Argon

SDS

RUO – Research Use Only