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  8. Methoxy-X04, Tocris Bioscience™

Methoxy-X04, Tocris Bioscience™

Catalog No. p-4817134 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Fluorescent amyloid β detector; brain penetrant

Methoxy-X04 is a fluorescent amyloid β (Aβ) probe for the detection and quantification of plaques, tangles and cerebrovascular amyloid. Methoxy-X04 Displays high in vitro binding affinity (Ki = 26.8 nM); binds selectively to fibrillar β-sheet deposits. Methoxy-X04 is a derivative of Congo Red (Cat. No. 5167). Methoxy-X04 can be used for in vivo Aβ plaque labeling. Methoxy-X04 co-localizes with CD68+ phagosomes in plaque-associated Iba1+ microglia; and it labels molecularly distinct plaque-associated microglia populations. Brain penetrant.

Chemical Identifiers

CAS 863918-78-9
Molecular Formula C23H20O3
Molecular Weight (g/mol) 344.41
InChI Key FGYNZFHVGOFCMD-KHVHPYDTSA-N
Synonym methoxy-x04, methoxy-04, 4,4'-2-methoxy-1,4-phenylenebisvinylene bisphenol, 4,4'-2-methoxy-1,4-phenylene di-1e-2,1-ethenediyl bisphenol
PubChem CID 16049314
IUPAC Name 4-[(E)-2-[4-[(E)-2-(4-hydroxyphenyl)ethenyl]-3-methoxyphenyl]ethenyl]phenol
SMILES COC1=C(C=CC(=C1)C=CC2=CC=C(C=C2)O)C=CC3=CC=C(C=C3)O

Specifications

Quantity 10 mg
Formula Weight 344.4
Percent Purity >98%
Chemical Name or Material Methoxy-X04

Safety and Handling

Recommended Storage Store at +4°C
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