Thermo Scientific Chemicals Mitomycin C, contains 2 mg Mitomycin C and 48 mg NaCl

Mitomycin C, CAS # 50-07-7, is a methylazirinopyrroloindoledione complex isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. It is a versatile and potent compound with antibiotic activity and may have potential therapeutic value in the treatment of cancer.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• Mitomycin C is a water soluble, blue-violet crystalline powder, unstable in light and acidic conditions, but may be stably stored at 2-8°c
• Bio-reduced mitomycin C generates oxygen radicals, alkylates DNA, and produces inter-strand DNA cross-links, thereby inhibiting DNA synthesis

Applications

• Mitomycin C is preferentially toxic to hypoxic cells that are resistant to cancer therapy, and is therefore used to study its potential therapeutic effect on advanced stages of cancer
• At high concentrations, mitomycin C inhibits RNA and protein synthesis and demonstrates strong antibiotic properties towards both Gram-positive and Gram-negative bacteria

Chemical Name or Material

Mitomycin C

CAS

50-07-7, 7647-14-5

Melting Point

>360.0°C

Color

Blue-Violet

Packaging

Ampoule

Molecular Formula

C₁₅H₁₈N₄O₅

Quantity

2 mg

MDL Number

MFCD00078109

Merck Index

15, 6300

Synonym

mitomycin c, mitomycin, ametycine, mutamycin, ametycin, mitocin-c, mitomycinum, mytomycin, mytozytrex, mitomycin-c

Solubility Information

Solubility in water: soluble. Other solubilities: soluble in methanol, acetone, butyl acetate and, cyclohexanone;, slightly soluble in benzene, ccl4, diethyl ether;, practically insoluble in petroleum ether.

InChI Key

NWIBSHFKIJFRCO-WUDYKRTCSA-N

SMILES

CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N

Molecular Weight (g/mol)

334.32

PubChem CID

5746

ChEBI

CHEBI:27504

Formula Weight

334.32

Percent Purity

≥99% with regard to the non-formulated material

Physical Form

Powder

SDS

SDS

RUO – Research Use Only