Thermo Scientific Chemicals Mitoxantrone Dihydrochloride

 

Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Chemical Identifiers

CAS

70476-82-3

Molecular Formula

C22H28N4O6.2HCl, C22H30Cl2N4O6

Molecular Weight (g/mol)

517.40

InChI Key

ZAHQPTJLOCWVPG-UHFFFAOYSA-N

Synonym

1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride;

IUPAC Name

dihydrogen 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione dichloride

SMILES

[H+].[H+].[Cl-].[Cl-].OCCNCCNC1=CC=C(NCCNCCO)C2=C1C(=O)C1=C(O)C=CC(O)=C1C2=O

Quantity

50 mg

Description

Blue to black

Content And Storage

-30°C to -10°C

Formula Weight

517.40

Solubility

Soluble to 5 mM in water and to 75 mM in DMSO

Product Type

Mitoxantrone dihydrochloride

Form

Crystalline solid

EINECSNumber

274-619-1

Recommended Storage

Store at -20°C

SDS

EINECSNumber

274-619-1

Recommended Storage

Store at -20°C

SDS

RUO – Research Use Only