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MK 0343, Tocris Bioscience™

Catalog No. 441510 Shop All R&D Systems Products
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Subtype-selective GABAA receptor partial agonist

Subtype-selective GABAA partial agonist (Ki values are 0.21, 0.22, 0.23 and 0.40 for α3, α1, α5 and α2 respectively); occupies the benzodiazepine site of GABAA receptors. Displays greater agonist efficacy at α3 compared to α1. Exhibits anxiolytic and non-sedating properties in rodent models. Brain penetrant.

Chemical Identifiers

CAS

233275-76-8

Molecular Formula

C19H17F2N7O

Molecular Weight (g/mol)

397.39

MDL Number

MFCD22683821

InChI Key

GOIFCXRIFSYPFG-UHFFFAOYSA-N

Synonym

unii-9vse02330i, 1,2,4-triazolo 4,3-b pyridazine, 7-cyclobutyl-3-2,6-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, mk hplc, 5-7-cyclobutyl-3-2,6-difluorophenyl-1,2,4 triazolo 4,3-b pyridazin-6-yl oxy methyl-1-methyl-1,2,4-triazole, 7-cyclobutyl-3-2,6-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4-triazo 4,3-b pyridazine

PubChem CID

22609888

IUPAC Name

5-({[7-cyclobutyl-3-(2,6-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1H-1,2,4-triazole

SMILES

CN1N=CN=C1COC1=NN2C(C=C1C1CCC1)=NN=C2C1=C(F)C=CC=C1F

Specifications

Quantity

10 mg

Formula Weight

397.38

Percent Purity

>99%

Chemical Name or Material

MK 0343

Recommended Storage

Store at +4°C
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