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(+)-MK 801 maleate, Tocris Bioscience™

Catalog No. 092450 Shop All R&D Systems Products
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Non-competitive NMDA antagonist; acts at ion channel site

(+)-MK 801 maleate is a high affinity (Ki = 37.2 nM), selective and non-competitive NMDA receptor antagonist. (+)-MK 801 maleate acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux. It is an effective anti-ischemic agent in several animal models. (+)-MK 801 maleate increases motor activity in rat models. (+)-MK 801 maleate inhibits proliferation and increases apoptosis in hippocampal neural stem cells (NSCs). (+)-MK 801 maleate induces schizophrenia-like symptoms in rodents.

(-)-enantiomer also available.

Chemical Identifiers

CAS

77086-22-7

Molecular Formula

C20H19NO4

Molecular Weight (g/mol)

337.375

InChI Key

QLTXKCWMEZIHBJ-PJGJYSAQSA-N

Synonym

dizocilpine maleate, +-mk-801 hydrogen maleate, +-mk 801 maleate, dizocilpine hydrogen maleate, unii-6lr8c1b66q, dizocilpine maleate usan, dsstox_cid_25785, dsstox_rid_81126

PubChem CID

6420042

SMILES

CC12C3=CC=CC=C3CC(N1)C4=CC=CC=C24.C(=CC(=O)O)C(=O)O

Specifications

Quantity

50 mg

Formula Weight

337.37

Percent Purity

>99%

Chemical Name or Material

(+)-MK 801 maleate

Recommended Storage

Store at Room Temperature
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