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ML 218 hydrochloride, Tocris Bioscience™

Catalog No. 450750 Shop All R&D Systems Products
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CaV3.x blocker

ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, Kir6 (KATP) or KV11.1 (hERG) potassium channels. ML 218 hydrochloride inhibits oral cancer cell proliferation. Orally active.

Chemical Identifiers

CAS

2319922-08-0

Molecular Formula

C19H27Cl3N2O

Molecular Weight (g/mol)

405.788

InChI Key

IDCVEUISZZKMKJ-ZXVFAPHLSA-N

Synonym

ml 218 hydrochloride, 3,5-dichloro-n-1?,5?,6-exo,6?-3-3,3-dimethylbutyl-3-azabicyclo 3.1.0 hex-6-yl methyl-benzamide hydrochloride

PubChem CID

90488946

IUPAC Name

3,5-dichloro-N-[[(1S,5R)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]benzamide;hydrochloride

SMILES

CC(C)(C)CCN1CC2C(C1)C2CNC(=O)C3=CC(=CC(=C3)Cl)Cl.Cl

Specifications

Quantity

50 mg

Formula Weight

405.79

Percent Purity

>99%

Chemical Name or Material

ML 218 hydrochloride

Recommended Storage

Store at +4°C
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