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MONNA, >98%, Tocris Bioscience™

Catalog No. 577050 Shop All R&D Systems Products
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Potent TMEM16A (Anoctamin-1) blocker

MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Carbachol (Cat. No. 2810) induced contraction of bronchial myocytes is reduced by MONNA and intracellular calcium release is increased.

Chemical Identifiers

CAS

1572936-83-4

Molecular Formula

C18H14N2O5

Molecular Weight (g/mol)

338.319

InChI Key

JIVRLHBAUUZTNC-UHFFFAOYSA-N

Synonym

monna, 2-4-methoxynaphthalen-2-yl amino-5-nitrobenzoic acid, 2-4-methoxynaphthalen-2-yl amino-5-nitrobenzoic, n-4-methoxy-2-naphthyl-5-nitroanthranilic acid, 2-4-methoxy-2-naphthalenyl amino-5-nitro-benzoic acid

PubChem CID

72165188

IUPAC Name

2-[(4-methoxynaphthalen-2-yl)amino]-5-nitrobenzoic acid

SMILES

COC1=CC(=CC2=CC=CC=C21)NC3=C(C=C(C=C3)[N+](=O)[O-])C(=O)O

Specifications

Linear Formula

C18H14N2O5

Quantity

50 mg

Solubility Information

Soluble to 100mM in DMSO

Formula Weight

338.31

Chemical Name or Material

2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid

Grade

>98%

Recommended Storage

Store at 4°C
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