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  8. MONNA, >98%, Tocris Bioscience™

MONNA, >98%, Tocris Bioscience™

Catalog No. p-7121263 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent TMEM16A (Anoctamin-1) blocker

MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Carbachol (Cat. No. 2810) induced contraction of bronchial myocytes is reduced by MONNA and intracellular calcium release is increased.

Chemical Identifiers

CAS 1572936-83-4
Molecular Formula C18H14N2O5
Molecular Weight (g/mol) 338.319
InChI Key JIVRLHBAUUZTNC-UHFFFAOYSA-N
Synonym monna, 2-4-methoxynaphthalen-2-yl amino-5-nitrobenzoic acid, 2-4-methoxynaphthalen-2-yl amino-5-nitrobenzoic, n-4-methoxy-2-naphthyl-5-nitroanthranilic acid, 2-4-methoxy-2-naphthalenyl amino-5-nitro-benzoic acid
PubChem CID 72165188
IUPAC Name 2-[(4-methoxynaphthalen-2-yl)amino]-5-nitrobenzoic acid
SMILES COC1=CC(=CC2=CC=CC=C21)NC3=C(C=C(C=C3)[N+](=O)[O-])C(=O)O

Specifications

Linear Formula C18H14N2O5
Quantity 10 mg
Solubility Information Soluble to 100mM in DMSO
Formula Weight 338.31
Chemical Name or Material 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
Grade >98%

Safety and Handling

Recommended Storage Store at 4°C
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