MilliporeSigma™ Mouse anti-α-syn (aa 115-122), Clone: LB509,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABN824

Catalog No. MABN824MI

Description

Specifically detects α-syn (aa 115-122) clone: LB509 in Human samples, and it is validated for Immunohistochemistry, Western Blotting

alpha-Synuclein is a small (140 amino acid) cytoplasmic protein of unclear function that is enriched in presynaptic terminals and is the precursor protein of a nonamyloid beta component of senile plaques in Alzeheimer's Disease (AD). α-Synuclein is located predominantly in the presynaptic nerve terminals in the brain but is also found in low concentrations in all tissues except liver. Studies have shown that abnormal aggregation and accumulation of synaptic proteins, including α-Synuclein, might be associated with plaque formation in AD and a major component of Lewy bodies in dementia with Lewy bodies (DLB). It has also been identified in the Glial Cytoplasmic Inclusions (GCIs) found in Multiple System Atrophy (MSA). Clone LB509 detects epitope in the region from amino acid 115 to 122 and has been used to characterize the digestion patterns of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al. 2013; PMID 23827677).

Specifications

• Antigen: α-syn (aa 115-122)
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: SNCA; NACP; PARK1
• Immunogen: Conjugated linear peptide corresponding to human α-syn (aa 115-122).
• Quantity: 100 μg
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_000336
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG1 κ

• Applications: Immunohistochemistry, Western Blot
• Clone: LB509
• Gene Accession No.: P37840
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only