N,O-Dimethylhydroxylamine hydrochloride, 98%, Thermo Scientific Chemicals

N,O-Dimethylhydroxylamine hydrochloride is used as a reagent in the preparation of 2-acyloxazoles from 2-oxazolemagnesium chloride and N-methoxy-N-methyl-3-oxo-butyramide from diketene. It is also used in amide coupling reactions to form Weinreb amides, which are useful in the Weinreb ketone synthesis. In addition, it is used in the preparation of an inhibitor of the NLS-derived BC peptides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
N,O-Dimethylhydroxylamine hydrochloride is used as a reagent in the preparation of 2-acyloxazoles from 2-oxazolemagnesium chloride and N-methoxy-N-methyl-3-oxo-butyramide from diketene. It is also used in amide coupling reactions to form Weinreb amides, which are useful in the Weinreb ketone synthesis. In addition, it is used in the preparation of an inhibitor of the NLS-derived BC peptides.

Solubility
Soluble in water, dimethyl sulfoxide and methanol.

Notes
Hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents.

Chemical Identifiers

CAS

6638-79-5

Molecular Formula

C2H8ClNO

Molecular Weight (g/mol)

97.54

MDL Number

MFCD00012485

InChI Key

USZLCYNVCCDPLQ-UHFFFAOYSA-N

Synonym

n,o-dimethylhydroxylamine hydrochloride, n,o-dimethylhydroxylamine hcl, n-methoxymethylamine hydrochloride, methanamine, n-methoxy-, hydrochloride, o,n-dimethylhydroxylamine hydrochloride, n-methoxymethanamine hydrochloride, o,n-dimethyl-hydroxylamine hydrochloride, methoxy methyl amine hydrochloride, n,o-dimethylhydroxyamine hydrochloride, n,o-dimethylhydroxylaminehydrochloride

PubChem CID

81138

SMILES

[H+].[Cl-].CNOC

Melting Point

112°C to 115°C

Quantity

100 g

Beilstein

3650353

Sensitivity

Hygroscopic

Solubility Information

Soluble in water,dimethyl sulfoxide and methanol.

IUPAC Name

N-methoxymethanamine;hydrochloride

Formula Weight

97.55

Percent Purity

98%

Chemical Name or Material

N,O-Dimethylhydroxylamine hydrochloride

Hazard Category

H315-H319

Hazard Statement

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

Precautionary Statement

P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362

EINECSNumber

229-642-1

TSCA

Yes

Recommended Storage

Ambient temperatures; Store under Nitrogen

SDS

Hazard Category

H315-H319

Hazard Statement

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

Precautionary Statement

P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362

EINECSNumber

229-642-1

TSCA

Yes

Recommended Storage

Ambient temperatures; Store under Nitrogen

SDS

RUO – Research Use Only