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Naloxone hydrochloride, 98%, Thermo Scientific Chemicals

Catalog No. AAJ60013ME
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Naloxone hydrochloride, CAS # 357-08-4, is involved in the blockade of the mu-opioid receptor and removal of other compounds from the receptor site.

A specific opiate antagonist. Blocks the action of sigma-agonists at opioid sites.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
• Naloxone hydrochloride the hydrochloride salt of the anti-opioid naloxone
Application
• Naloxone is a fast-acting inverse agonist of the mu-opioid receptor that can be used to competitively inhibit the binding of opioid compounds

Chemical Identifiers

CAS

357-08-4

Molecular Formula

C19H22ClNO4

Molecular Weight (g/mol)

363.838

MDL Number

MFCD00069322

InChI Key

RGPDIGOSVORSAK-STHHAXOLSA-N

Synonym

naloxone hydrochloride, naloxone hcl, narcan, evzio, unii-f850569pqr, nalonee, 17-allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride, narcan tn, naloxonehydrochloride

PubChem CID

5464092

IUPAC Name

(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride

SMILES

C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl

Specifications

Melting Point

200°C to 205°C

Color

White

Quantity

500 mg

Merck Index

14,6362

Solubility Information

Soluble in water (73mg/ml),ethanol (3.3mg/ml),methanol (50mg/ml) and dimethyl sulfoxide (73mg/ml). Insoluble in ether

Formula Weight

363.84

Percent Purity

98%

Physical Form

Crystalline Powder

Chemical Name or Material

Naloxone hydrochloride

Hazard Category

H302-H315-H319-H335

Hazard Statement

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

Precautionary Statement

P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c

EINECSNumber

206-611-0

RTECSNumber

QD2275000

TSCA

No

storageNote1

2° to 8°C

Recommended Storage

Keep cold
SDS

RUO – Research Use Only

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