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Naringin, Thermo Scientific Chemicals

Catalog No. AAJ6316614
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A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activity

A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activityNaringin is used to prepare naringin dihydrochalcone, which is about 300-1800 times sweeter than sugar. It is a citrus bioflavonoid reported to inhibit cytochrome P450 monooxygenase activity. It also acts as an inhibitor of cytochrome P450 enzymes. It is employed as an antioxidant, lipid lowering and anticancer agent. In addition to this, it is used in a study to assess aldosterone production by a human adrenocortical cell line and to improve cognitive deficits of Alzheimer's disease.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activityNaringin is used to prepare naringin dihydrochalcone, which is about 300-1800 times sweeter than sugar. It is a citrus bioflavonoid reported to inhibit cytochrome P450 monooxygenase activity. It also acts as an inhibitor of cytochrome P450 enzymes. It is employed as an antioxidant, lipid lowering and anticancer agent. In addition to this, it is used in a study to assess aldosterone production by a human adrenocortical cell line and to improve cognitive deficits of Alzheimer′s disease.

Solubility
Soluble in water, alcohol, acetone and warm acetic acid.

Notes
Incompatible with strong oxidizing agents.

Chemical Identifiers

CAS

10236-47-2

Molecular Formula

C27H32O14

Molecular Weight (g/mol)

580.54

MDL Number

MFCD00148888,MFCD00149445,MFCD01461988

InChI Key

DFPMSGMNTNDNHN-ZPHOTFPESA-N

Synonym

4',5,7-Trihydroxyflavanone 7-rhamnoglucoside

PubChem CID

74787988

IUPAC Name

7-[(2S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one

SMILES

C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2OC2=CC(O)=C3C(=O)C[C@H](OC3=C2)C2=CC=C(O)C=C2)[C@H](O)[C@H](O)[C@H]1O

Specifications

Color

White to Yellow

Quantity

25 g

Beilstein

102012

Merck Index

14,6425

Solubility Information

Soluble in water,alcohol,acetone and warm acetic acid.

Formula Weight

580.53

Physical Form

Powder

Chemical Name or Material

Naringin

Hazard Category

Warning

Hazard Statement

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

Precautionary Statement

GHS P Statement
P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

EINECSNumber

233-566-4

RTECSNumber

QN6340000

TSCA

Yes

Recommended Storage

Ambient temperatures
SDS

RUO – Research Use Only

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