Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

NBI 35965 hydrochloride, Tocris Bioscience™

Catalog No. 310050 Shop All R&D Systems Products
Click to view available options
Quantity:
This item is not returnable. View return policy
This item is not returnable. View return policy

Potent and selective CRF1 antagonist

Potent and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist (Ki values are 4 and > 10000 nM at CRF1 and CRF2 respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50 values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo. Orally active and brain penetrant with anxiolytic activity.

Chemical Identifiers

CAS

603151-83-3

Molecular Formula

C21H23Cl3N4

Molecular Weight (g/mol)

437.793

InChI Key

LNYUWBPFYXPUIO-RSAXXLAASA-N

Synonym

nbi 35965 hydrochloride, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-4-methyl-7,8-dihydro-6h-1,3,6,8a-tetraazaacenaphthylene-hydrogen chloride 1/1, 7s-6-cyclopropylmethyl-2-2,4-dichlorophenyl-7-ethyl-7,8-dihydro-4-methyl-6h-1,3,6,8a-tetraazaacenaphthylene hydrochloride

PubChem CID

71433630

SMILES

CCC1CN2C3=C(C(=N2)C4=C(C=C(C=C4)Cl)Cl)N=C(C=C3N1CC5CC5)C.Cl

Specifications

Quantity

50 mg

Formula Weight

437.79

Percent Purity

>98%

Chemical Name or Material

NBI 35965 hydrochloride

Recommended Storage

Store at Room Temperature
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.