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Necrostatin-1, Thermo Scientific Chemicals

Catalog No. AAJ65341FPL
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Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any pe

Chemical Identifiers

CAS

4311-88-0

Molecular Formula

C13H13N3OS

Molecular Weight (g/mol)

259.327

MDL Number

MFCD00056916

InChI Key

TXUWMXQFNYDOEZ-UHFFFAOYSA-N

Synonym

necrostatin-1, mth-dl-tryptophan, nec-1, necrostatin 1, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo-4-imidazolidinone, mth-trp, methyl-thiohydantoin-tryptophan, necroptotic inhibitor, nec-1, 5-1h-indol-3-ylmethyl-3-methyl-2-sulfanylideneimidazolidin-4-one, 4-imidazolidinone, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo

PubChem CID

2828334

IUPAC Name

5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one

SMILES

CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32

Specifications

Color

Yellow

Quantity

20 mg

Sensitivity

Light sensitive

Solubility Information

Soluble in DMSO (10-25mg/ml),100% ethanol (6mg/ml),and methanol (5mg/ml).

Formula Weight

259.33

Physical Form

Powder

Chemical Name or Material

Necrostatin-1

TSCA

No

storageNote1

2° to 8°C

Recommended Storage

Keep cold
SDS

RUO – Research Use Only

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