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TARGETMOL CHEMICALS INC NEFERINE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Neferine ((-)-Neferine) has anti-tumor activities Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to achieve anticancer synergism by curbing the toxicity. 3. Neferine inhibited high glucose-induced endothelial apoptosis via blocking ROS/Akt/NF-(kappa)B pathway which provides the evidence for using Neferine to treat diabetic vasculopathy. 4. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species activation of MAPKs lipid peroxidation depletion of cellular antioxidant pool loss of mitochondrial membrane potential and intracellular calcium accumulation. purity: 99%
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