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NGB 2904, Tocris Bioscience™

Catalog No. p-4784192 Shop All R&D Systems Products
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Potent and selective D3 antagonist

NGB 2904 is a potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). Potently antagonizes quinpirole -stimulated mitogenesis (IC50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.

Chemical Identifiers

CAS

189061-11-8

Molecular Formula

C28H30Cl3N3O

Molecular Weight (g/mol)

530.918

InChI Key

PFIWYJNBKGCVFM-UHFFFAOYSA-N

Synonym

ngb 2904 hydrochloride, n-4-4-2,3-dichlorophenyl-1-piperazinyl butyl-9h-fluorene-2-carboxamide, n-4-4-2,3-dichlorophenyl-1-piperazinyl butyl-9h-fluorene-2-carboxamide hydrochloride, 28h29cl2n3o.hcl, ngb 2904 hydrochloride hplc, n-4-4-2,3-dichlorophenyl piperazin-1-yl butyl-9h-fluorene-2-carboxamide hcl, n-4-4-2,3-dichlorophenyl piperazin-1-yl butyl-9h-fluorene-2-carboxamide hydrochloride

PubChem CID

19366304

IUPAC Name

N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-9H-fluorene-2-carboxamide;hydrochloride

SMILES

C1CN(CCN1CCCCNC(=O)C2=CC3=C(C=C2)C4=CC=CC=C4C3)C5=C(C(=CC=C5)Cl)Cl.Cl

Specifications

Quantity

10 mg

Formula Weight

530.92

Percent Purity

>98%

Chemical Name or Material

NGB 2904

Recommended Storage

Desiccate at +4°C
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